Two people are dead and nine more are injured after the minibus they were in crashed in to a tree.
The bus was travelling south along the Calder Highway at Carwarp, about 30km south of Mildura, about 7.45am on Tuesday when it rolled on to its side and in to a tree.
Police say two people died at the scene and the male driver has been taken to hospital with critical injuries.
One passenger also sustained critical injuries and has been flown to a Melbourne hospital for treatment.
Three passengers with serious injuries were taken to Mildura Base Hospital and four more were taken in for observation.
Police are investigating the cause of the crash and the Calder Highway between Kulkyn Way and Brownport Road is expected to be closed for several hours.