UPDATE, 7.45pm:
Both roads are now open to traffic.
UPDATE, 7.25pm:
Further details have emerged about a crash at Tatura today.
Tatura Police Sergeant Darryl Phillips said a Holden Commodore travelling west on Toolamba-Rushworth Rd and a Ford Territory travelling south on Tatura-Murchison Rd collided at 4.50pm.
The high-speed impact pushed both vehicles off to the western side of the Tatura-Murchison Rd.
The Commodore ended up in water in a ditch on the side of the road, and the Territory was almost in the drainage channel.
One of the vehicles was towing a trailer, which ended up in the drainage channel.
The single occupant of the Territory was a 53-year-old man from Violet Town.
The Commodore had three occupants – a 29-year-old man and 23-year-old woman from Merrigum, and a 32-year-old Shepparton woman.
The Merrigum man and woman were taken by air ambulance to Shepparton Airport and then airlifted to a Melbourne hospital.
The other two were taken to Goulburn Valley Health by road ambulance.
Both roads were closed for two hours after the crash.
Toolamba-Rushworth Rd has opened, and Tatura-Murchison Rd remains blocked.
Police are investigating the cause of the crash.
Any witnesses to the crash are asked to call Tatura Police on 5824 3099 or Crime Stoppers on 1800 333 000 or online at crimestoppersvic.com.au
UPDATE, 6.25pm:
An Ambulance Victoria spokesperson said two people were airlifted to hospital following a two-vehicle crash at the intersection of Murchison-Tatura Rd and Toolamba-Rushworth Rd.
A woman is being treated for a back injury and is in a serious but stable condition.
A man is also being treated for a back injury and is in a stable condition.
Another patient is being taken to Goulburn Valley Health by road ambulance in a stable condition.
UPDATE, 6.10pm:
Police, ambulance, Tatura SES, Shepparton Search and Rescue, and fire brigade are on the scene of a crash at Tatura.
Currently, both Murchison-Tatura Rd and Toolamba-Rushworth Rd are closed, and motorists should seek alternate routes.
Traffic is being diverted.
EARLIER, 5.30pm, Wednesday, November 22:
Emergency services are responding to a two-vehicle crash at Tatura on Wednesday, November 22.
The crash is believed to have happened at about 4.45pm at the intersection of Murchison-Tatura Rd and Toolamba-Rushworth Rd.
An Ambulance Victoria spokesperson said paramedics were called to Tatura just before 5pm to a report of a collision. At this stage, it appears four people are being assessed at the scene.