A woman in her 50s has been airlifted to The Alfred following a car crash at the intersection of Echuca-Nanneella Road and Odea Rd, Strathallan, about 7.15am on Wednesday.
She is in a stable condition with upper and lower body injuries.
A man in his 20s was taken to Bendigo Health in a stable condition with no obvious injuries.
Echuca Highway Patrol are currently investigating the circumstances surrounding the crash and have stated they will know more about the cause of the crash once the conditions of the patients have improved.